Duodenal and Small Intestinal Manifestations of Systemic Autoimmune Diseases Kunihiko Aoyagi 1 , Yoshitaka Tomioka 1 , Takashi Watanabe 1 , Kenji Ikeda 1 , Eiji Fujita 1 , Kazuhiro Maeda 1 , Koichi Eguchi 1 , Shotaro Sakisaka 1 1Department of Gastroenterology and Medicine, Fukuoka University School of Medicine, Fukuoka, Japan Keyword: 膠原病 , 全身性自己免疫疾患 , 血管炎 , 小腸 , 十二指腸 pp.1013-1019
Published Date 2009/5/25
DOI https://doi.org/10.11477/mf.1403101686
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 Systemic autoimmune diseases, known as collagen diseases, are a group of various connective tissue diseases and vasculitis syndrome. Serious gastrointestinal complications such as ulcers, hemorrhage and perforation are important factors to be considered in any prognosis. 33 patients with duodenal and small intestinal involvement were analyzed by radiographic and endoscopic findings. Identified lesions included ulcers in 15 patients(45%), erythema/erosion in 12(36%), edema in 11(33%), granular mucosa in 5(33%), luminal dilatation in 4(12%). Ulcers were more frequent in vasculitis-associated disorders, whereas luminal dilatations were more frequent in vasculitis-nonassociated disorders. These results indicate that there is a high prevalence of ulcers in the duodenum and small intestine in systemic autoimmune diseases.

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