Eosinophilic Esophagitis Yuichiro Tomomatsu 1 , Junji Yoshino 1 , Kazuo Inui 1 , Takao Wakabayashi 1 , Yoshiaki Katano 1 , Takashi Kobayashi 1 , Hironao Miyoshi 1 , Toshihito Kosaka 1 , Satoshi Yamamoto 1 , Hironao Matsuura 1 , Yasuki Narita 1 , Yoshinori Torii 1 , Tomoko Mori 1 , Yuuji Yasue 1 , Yuuta Kurokawa 1 , Chikao Hosokawa 1 1Department of Internal Medicine, Banbuntane Hotokukai Hospital, Fujita Health University, School of Medicine, Nagoya, Japan Keyword: 好酸球性食道炎 , eosinophilic esophagitis , アレルギー疾患 , 縦走溝 , 超音波内視鏡検査 pp.1873-1881
Published Date 2013/12/25
DOI https://doi.org/10.11477/mf.1403114018
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 EoE(eosinophilic esophagitis)is a chronic allergic disease characterized by eosinophilic infiltration of the esophageal epithelium. Records of 17 patients diagnosed with EoE at our hospital between May, 2010 and April, 2013 were examined for age, sex, symptoms, endoscopic findings, and treatment. Patients were 70.6% males with a mean age of 49 years. Symptoms included heartburn, dysphasia, and food impaction. Endoscopic findings of EoE include longitudinal furrows, mucosal edema, loss of vascular pattern, rings, and white exudates. Histopathological examination revealed eosinophilic infiltration(≧15 eosinophils/high-powered field)in the esophageal epithelium of all patients. PPI(proton pump inhibitor)therapy was administered as the first-line treatment but was ineffective in 6 patients out of 10. Steroid therapy was administered to 4 patients unresponsive to PPI therapy and was effective. EoE has received increased attention due to the recent increase in its prevalence. It is important that physicians engaging in endoscopy and pathologists should be aware of EoE.

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