Primary Esophageal Endocrine Cell Carcinoma, Report of a Case Manabu Takeuchi 1 , Gen Watanabe 2 , Masaaki Kobayashi 3 , Satoru Hashimoto 3 , Ken-ichi Mizuno 3 , Yuichi Sato 1 , Yoichi Ajioka 2 , Yutaka Aoyagi 1 1Department of Gastroenterology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan 2Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan 3Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata, Japan Keyword: 食道癌 , 神経内分泌細胞癌 , 隆起型 , NBI , 特殊組織型 pp.362-368
Published Date 2013/3/25
DOI https://doi.org/10.11477/mf.1403113752
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 A female in her sixties. The conventional esophagoscopy showed a reddish flat elevated lesion and a protruded lesion with central slight depression on the posterior wall of the upper to lower thoracic esophagus. The protruded lesion had overall thickness and hardness. Only the central depression of the protrusion was unstained with iodine. The magnifying endoscopy with NBI revealed Type B2 showing an irregular branched, reticular microvessel(type 4R)without forming AVA and Type B3 consisting of vessels three times or more thicker than Type B2. EUS(IDUS, 20MHz)showed a hypo echoic mass lesion invading to the SM deep layer.

 We diagnosed the lesion as a special variant of esophageal carcinoma or poorly differentiated squamous cell carcinoma because the lesion revealed a protrusion covered partly with normal epithelium and irregular branched, reticular vascular pattern. Video-Assisted Thoracic Surgery for the Esophagus with three-field lymph node dissection was performed. Histologically, the tumor was diagnosed as endocrine cell carcinoma pT1b(SM3), ly0, v0, pPM0, pVM0, pRM0, n(-). Immmunohistochemically, CD56 and chromogranin A were positive for the tumor cells.

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