Stomach and Intestine(Tokyo) Volume 11, Issue 7 (July 1976)

Follow-up Studies of Morphological Changes in N-methyl-N'-nitro-N-nitrosoguanidine Carcinogenesis in Stomach of Dogs: III. Growth of a depressed-type stomach carcinoma. T. Saito 1 , R. Tamada 1 , O. Sasaki 1 , K. Soejima 1 , K. Inokuchi 1 , M. Hirano 2 12nd Department of Surgery, Faculty of Medicine, University of Kyushu 22nd Department of Surgery, Faculty of Medicine, Fukuoka University pp.927-934
Published Date 1976/7/25
  • Abstract
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 Follow-up studies by endoscopy and biopsy of a stomach carcinoma induced by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG) in a dog, No. 3, and necropsied findings of the stomach are described. IIc-like early carcinoma at the posterior wall side of the gastric angle gradually enlarged and became a deep depressed lesion with irregular marginal elevation, a so-called Borrmann 2 type in appearance at 115 weeks. Thereafter, it changed to a Borrmann 3 type-carcinoma at 181 weeks. Meanwhile, by the 170th week, a new shallow depressed lesion appeared at the anterior wall side of the angle. The lesion in the anterior wall side developed in the rate considerably rapid and was associated with the predominant lesion in the posterior wall side at 181 weeks. Biopsy revealed tubular adenocarcinoma in the former, and signet ring cell carcinoma with tubular adenocarcinoma in the latter. After steady development of stomach carcinoma over 2 years, the dog died of liver abscess at 216 weeks. Necropsy revealed a tubular adenocarcinoma infiltrating the serosal membrane at two points of the antral portion corresponding to cancerous lesions of anterior and posterior wall sides of the angle. Metastasis to a celiac lymph node was confirmed.

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11巻7号 (1976年7月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院