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So-called “Brown Bowel”: a Pathologic and Etiologic Study S. Moriwaki 1 , O. Ochi 2 1Matsuyama National Hospital, Department of Pathology 2Ehime Univ. Department of Biology pp.1327-1335
Published Date 1974/10/25
DOI https://doi.org/10.11477/mf.1403111830
  • Abstract
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 The brown pigmentation of the recto-colonic mucosa called melanosis coli is not a rare condition, and numerous clinical and pathological studies have been reported, but the nature and significance of the pigments remains to be elucidated.

 We have studied the clinico-pathologic, especially histochemic and electron-microscopic observation of the large bowel during a period of seven years and a half in our hospital.

 The incidence of deposition of brown pigments in the human large bowel were found in 217 cases (34.9%) of 622 materials, -117 in 361autopsies, 86 in 177 operations and 14 in 84 biopsies. The frequency is higher in lower abdominal tumors-female sex organs (66.7%), urinary organs (63.2%) and large bowel (61.5%).

 On light microscopic observations, the pigments were revealed to be similar to the lipofuscin in various staining. Electron-microscopically, the pigments differed from lipofuscin, hemosiderin and melanotic pigments. The pigments-conteining cells-phagcytes -were found in the mucosa and submucosa of the large bowel. The pigments changed from autophagosomes to autolysosomes and finally to residual bodies in phagocytes. Regarding the pigmentation we consider that chronic static contents of digestive tract are absorbed from the surface of the superficial lining cells, and then they are transmitted to the phagocytes in the tunica mucosa as hetrophagosomes. However, our present observation could not reveal the transforming process of pre-pigmented materials in epithelial cells.

 One of the most important causes of pigmentation is chronic stasis of ingested materials in the digestive tract in various conditions.

 The processes of pigmentations are related with lysosomes and a condition of lysosomal storage lesions.


Copyright © 1974, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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