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A CASE OF HEMOPHILIA WITH AN ATYPICAL EPITHELIUM IN A PROTRUDING LESION OF THE STOMACH Michio Ohtsuki 1 1Department of Surgery, School of Medicine, Keio University pp.1567-1572
Published Date 1968/11/25
DOI https://doi.org/10.11477/mf.1403110664
  • Abstract
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 A 55 years old man who had been in good health was found to have a lesion in the stomach. Subsequent X-ray examinations were suggestive of the presence of Ⅱa type early gastric cancer. Concomitantly, he was shown to have hemophilia B, ascertained by laboratory data, including abnormally prolonged coagulation time (30'30”) and decreased PTC.

 Gastrectomy was performed under careful management inclusive of plasma and whole blood transfusion and administration of hemostatic agents. Surgical procedure was uneventful.

 In the resected stomach, well circumscribed protruding lesion, 4.5 cm by 4.0 cm in size, composed of several hemispheric mucosal elevations, was noted on the posterior wall of the corpus. Microangiogram revealed irregular arborization and dilatation of mucosal vessels. Microscopically, a highly hyperplastic atypical epithelium was found in the involved area without any trace of malignancy.

 In recent years, reports of cases of atypical epithelium associated with protruding lesions in the stomach have been increasing in Japan. According to the literature thereupon and on the basis of the experience with five such cases in the authors' clinic, its characteristic features are summarized as follows.

 1. No complaints are usually present.

 2. Achylia gastrica is commom.

 3. Macroscopically it is seen as plateau-like or hemispheric mucosal protrusion, mostly less than 2cm in diameter, sometimes more than 4cm as exemplified in this case.

 4. Microscopically, hyperchromatic epithelium is noted on the surface of the protruding mucosal area, and gastric glands with cystic dilatation are seen in the basal portion of the mucosa.

 As for the diagnostic procedures, gastroscopic biopsy seems to be the method of choice.

 In conclusion, it is mentioned that, although atypical epithelia as a clinical entity have been the subject of much controversy, especially with regard to their origin, neoplastic or otherwise, correct diagnosis and elimination of any other co-existent malignancy is essential before giving an indication for operative surgery or for further observation.


Copyright © 1968, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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