“NON SPECIFIC MULTIPLE ULCERS OF THE SMALL INTESTINE” Haruya Okabe 1 , Masahiro Sakimura 1 1Second department of internal medicine, Faculty of Medicine, Kyushu University pp.1539-1549
Published Date 1968/11/25
DOI https://doi.org/10.11477/mf.1403110660
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 The present study is designed to describe clinical and pathological details of six cases characterized by non-specific multiple ulcerations of the upper, and a part of the lower, ileum.

 The most outstanding clinical manifestation common to all these cases is long history of persistent intestinal bleeding with secondary anemia, accompanied by hypoproteinemia, retardation of growth, and varying degrees of abdominal pain. Although some of these signs and symptoms may resemble those of ileojejunitis, there is some disparity between severe intestinal bleeding in these cases and the clinical pictures of regional enteritis. Discrepancy is also seen in the pathological findings, since the latter is characterized by marked proliferative reactions, as manifested by the predominance of tubercle-like granuloma and pronounced fibrous changes, while in all of six cases here presented fibrosis of the submucosa is not prominent and tubercle-like granuloma is nowhere to be seen.

 On the basis of these clinical and pathologiacl observations, it is suggested that these cases should be called as “non-specific multiple ulcers of the small intestine” as distinguished from regional enteritis until proved to the contrary.

Copyright © 1968, Igaku-Shoin Ltd. All rights reserved.


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