Japanese

Endocrine Cell Disorder in Chronic Gastritis Minoru Itsuno 1 , Hedenobu Watanabe 1 , Mitsuya Iwabuchi 1 , Noriko Ishihara 1 , Masanori Kikuchi 2 , Kouji Sato 3 , Nobuhiro Akiyama 3 , Kazue Ogoshi 3 1The First Department of Pathology, Niigata University, School of Medicine 2Department of Pathology, The University of Tsukuba, School of Medicine 3Division of Internal Medicine, Cancer Center Niigata Hospital pp.635-649
Published Date 1985/6/25
DOI https://doi.org/10.11477/mf.1403109878
  • Abstract
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 Endocrine cell micronests (ECMs) occurred in the reversed atrophic type gastritis (type A gastitis) and common type atrophic gastritis (type B gastritis) respectively, were studied. ECMs in both types of gastritis developed from the fundic glands, pseudopyloric glands and pyloric glands. ECMs were formed mainly by the atrophy and disappearance of these glands and partly by the separation following budding of intraglandular endocrine cells. The kinds of endocrine cells constituting ECMs in the common type atrophic gastritis were similar to those distributed in the proper gastric glands, from which ECMs developed. It was proved that ECMs and carcinoids in the atrophic fundic mucosa of the reversed atrophic type gastritis were hyperplasia and/or neoplasia of ECL cells caused by the trophic action of the subsequently raised serum gastrin.

 As the conclusion of our comparative study on ECMs occurred in both types of atrophic gastritis, neoplastic ECMs (microcarcinoids) of the stomach were defined as follows: (1) ECMs larger than 0.1 mm in the largest diameter,(2) ECMs, even if smaller than 0.1mm, invading the muscularis mucosae or submucosa, or (3) ECMs, even if smaller than 0.1mm, composed of large endocrine cells with a large nucleus.


Copyright © 1985, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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