Colonic Crohn's Disease with Atypical Macroscopic Features, Report of a Case Kazuya Makiyama 1 , Yoji Sakaguchi 2 , Kinpei Kubo 2 , Minoru Itsuno 5 , Hidenobu Watanabe 5 1The Second Departrent of Internal Medicine, School of Medicine, Nagasaki University 2Kubo Hospital 5The First Department of Pathology, Faculty of Medicine, Niigata University pp.107-114
Published Date 1988/1/25
DOI https://doi.org/10.11477/mf.1403107836
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 A 35 year-old woman was admitted to our hospital on May 10, 1984 because of diarrhea. She had been hospitalized twice in the previous seven years because of diarrhea, which started for the first time in July, 1978. On physical examination the patient was emaciated with left abdominal tumor and a small perianal fistula (Fig. 3 a).

 Findings of periodical barium enema were as follows: many small ulcers in the transverse and descending colon and a few niches in the ascending colon in Oct., 1978 (Fig. 1 a); emergence of pseudopolyps after medical treatment in Dec., 1978 (Fig. 1 b); transformation into segmental stenosis of the entire descending colon with cobblestone appearance and a few fissurings in May, 1984 (Fig. 1 c); and stenosis with inflammatory polyposis (Fig. 2 a, b) and small aphthoid lesions in the rectum (Fig. 2 c) in June 1984. The colonoscopic examination showed reddish polyps on the anal side of the stenosis (Fig. 3 b) and almost normal rectal mucosa (Fig. 3 c). After application of methylene blue to the rectal mucosa, magnifying endoscopy revealed so-called “worm-eaten” appearance (Fig. 3 d). Biopsy specimens from these lesions looked almost normal partly with some giant cells in the granulation tissue.

 Since medical treatment was not effective in relieving stenosis, a partial colectomy was performed in July, 1984. Macroscopic examination of the resected specimens showed segmental stenosis of the entire descending colon with inflammatory polyps scattered in the atrophic mucosa (Fig. 4 a). Histologically, there were many non-caseating epithelioid cell granulomas throughout the entire layers, transmural inflammation composed mainly of aggregates of lymphocytes and multiple healed scars of serpiginous and longitudinal shape (Figs. 4 b and 5 a-d).

 Postoperative course was uneventful, and the patient has been asymptomatic without evidence of recurrence for the following 10 months.

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