食道癌の発育進展―逆追跡症例を中心に

Growth of Esophageal Cancer by Retrospective Follow-up Study of Esophagographies

要旨　食道扁平上皮癌と診断した症例で，過去に撮影されたX線写真の得られたものについて検討を加えた．X線学的に逆追跡が可能であった症例について，癌発育速度を検討した．腫瘍容積倍増時間は草間による式を用いた（14症例）．壁深達度進展期間は逆追跡可能であったX線写真（15病変）について深達度を推定し，切除後の組織学的深達度と対比検討した．その結果，腫瘍容積倍増時間は平均6.30か月であったが，1か月以内の短いもの，1年以上の長いものもあり差がみられた．深達度進展は，m癌からsm癌までは12か月とやや長かったが，sm癌からa₂，a₃の進行癌までは6か月と短く，急速に進展するように思われた．

　Evaluations were made about cases that were diagnosed as squamous cell carcinoma, and in which x-ray pictures taken in the past were obtainable. In the cases in which retrospective radiological study was possible, cancer growth speed was investigated. For doubling time, the formula by Kusama was applied (14 cases). X-ray pictures taken previously of lesions in 15 cases were used to try to determine the wall-invasion rate.

　By comparing histological finding showing the depth of invasion found after resection with progression of the carcinomas shown in the x-ray pictures, a hypothesis was able to be formulated.

　Doubling time was on an average 6.30 months but there were exceptions e.g.－doubling time of within a period of one month, as well as doubling time over very long periods.

　It took a rather long time (12 months) for the invasion to double its depth in the stage going from m cancer to sm cancer. However, in the stage from sm cancer to a₂ or a₃, the time required for cancer to double its depth was shorter (6 months), so it can be thought that the invasion rate becomes more rapid as the cancer's depth increases.