Argyrophil and Argentaffin Cells in Carcinomas of the Small Intestine A. Iwashita 1 , H. Kido 1 , M. Enjoji 1 1The Second Department of Pathology, Kyushu University Faculty of Medecine pp.1029-1039
Published Date 1981/9/25
DOI https://doi.org/10.11477/mf.1403108204
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 Incidence, distribution and morphology of neoplastic argyrophil and argentaffin cells were studied in 16 surgical cases of adenocarcinoma of the small intestine. Whole tissue sections cut through the major axis of each tumor were stained by Grimelius' method for both argyrophil and argentaffin cells and by FontanaMasson method for argentafftn cells. In addition, special preparations were made by combined Grimeliusalcian blue method.

 Neoplastic argyrophil and argentaffin cells were found in 11(68.8%) and seven(43.8%) respectively, of these 16 tumors. Of the positive cases seven contained both argyrophil and argentaffin cells in the same tumor and the number of the former cells was always larger than that of the latter. The argyrophil cells were demonstrated in all of the four tumors of the ileum, in five of the six tumors of the jejunum and in two of the six tumors of the duodenum other than periampullary tumors. The argentaffin cells were also found most often in ileal tumors(75%) and least often in duodenal tumors(16.7%). These cells were recognized only in cases with well differentiated adenocarcinoma, were found almost equally within the tumor tissue by different layers of the intestinal wall, except for the subserosal layer where contained only a few such cells invariably, and were present even in metastatic sites. Distribution of these cells within the tumor tissue was usually focal, though diffuse in two tumors. These cells were flask-like or cylindrical in shape and the characteristic brown to black granules were commonly situated in the infranuclear cytoplasm. Out of 11 tumors double-stained by the Grimeliusalcian blue method, none contained any cells having both argyrophil granules and mucus together.

 Argyrophil and argentaffin cells within the tumor tissue are assumed to be integral components of the tumors and to have arisen by divergent differentiation of the more primitive neoplastic cells. It is indicated that a true carcinoid tumor belongs both basically and clinicopathologically to a different category from carcinomas with argyrophil and/or argentaffin cells in discussion.

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