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orphologic Alterations of Polyps during a Long-term Follow-up Study of Non-operated Familial Adenomatosis Coli M. Maruyama 1 1Department of Internal Medicine, Cancer Institute Hospital pp.639-658
Published Date 1984/6/25
DOI https://doi.org/10.11477/mf.1403107048
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 A long-term follow-up study by x-ray and endoscopy was done to the patients with familial adenomatosis coli (FAC) who refused surgery in the first examination by x-ray or endoscopy. Morphologic alterations of polyps had been observed in five cases for more than seven years (the shortest seven years and one month, and the longest eleven years and nine months).

 Density of polyps did not change during the observation periods in four cases (p>0.1), and it became higher in about seven years in one case (p<0.01). It was suggested that there is a static phase of the density of polyps for a long time in FAC, which is followed by a changing phase. On the other hand, size of polyps increased gradually in five cases (p<0.001). It was suggested that there is also a static phase of the size of polyps, which may be shorter than that of the density of polyps.

 There were several polyps which showed a marked increasing tendency of size, but they did not always develop into cancer. Two lesions developed into advanced cancers in one case, and one of them could not be detected until surgery. One lesion developed into cancer with submucosal involvement in one case. Some lesions remained pedunculated, though their size was over 4 cm. Not only size but also form of the lesions should be considered for the differential diagnosis of adenoma and cancer.

 It is hazardous to attempt follow-up study of FAC. Doctors' efforts should be directed to persuading the patients with FAC to accept early surgery.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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