Acute Intestinal Graft-Versus-Host Disease (GVHD), Report of a Case Kurato Yashiro 1 , Kou Nagasako 1 , Hiroshi Saito 2 , Kazuo Oshimi 2 , Hideaki Mizoguchi 2 1Institute of Gastroenterology, Tokyo Women's Medical College 2Institute of Hematology, Tokyo Women's Medical College pp.1137-1143
Published Date 1989/10/25
DOI https://doi.org/10.11477/mf.1403106586
  • Abstract
  • Look Inside
  • Cited by

 Colonoscopic observation was made on intestinal GVHD. The patient was 29-year-old male with myeloblastic leukemia which was diagnosed in 1981 and necessitated bone marrow transplantation on January 7, 1986. Eruption occurred 20 days later and biopsy of the skin led to the diagnosis of acute GVHD. Liver dysfunction and bloody diarrhea ensued 40 days later and colonoscopy and upper GI endoscopy were performed. Multiple erosions were found in the colon, terminal ileum and upper jejunum. Examination of the biopsy specimen from the upper jejunum showed denudation of the epithelium due to the vacuolated basal layer. The erosive lesions diappeared 90 days after the onset of bloody diarrhea.

 The patient, however, died of interstitial pneumonia on April 9, 1987.

Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院