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Japanese

Minute Depressed Adenomas of the Large Intestine in Patients with Familial Adenomatous Polyposis (FAP) Dissecting Microscopical, Histological, and Morphometrical Studies Osamu Kubota 1 , Isamu Kino 1 , Tomio Arai 1 , Shin-ichi Nakamura 2 , Shozo Baba 3 1The First Department of Pathology, Hamamatsu University School of Medicine 2Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University 3The Second Department of Surgery, Hamamatsu University School of Medicine Keyword: 家族性大腸腺腫症 , 実体顕微鏡 , 形態計測 , 陥凹型腺腫 , 隆起型腺腫 pp.833-841
Published Date 1995/5/25
DOI https://doi.org/10.11477/mf.1403105438
  • Abstract
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 Of the 26 large intestines with familial adenomatous polyposis (FAP) we systematically examined 100 colorectal polypoid and 100 depressed adenomas less than 2.0 mm in diameter. Generally, depressed adenomas less than 1.0 mm in diameter grew horizontally, while in those more than 1.0 mm in diameter their whole appearance showed vertical growth, and transitional types developing into polypoid adenomas were often seen among larger ones. However, adenomas which showed marked depression of their adenomatous crypts in spite of being more than 1.0 mm in diameter were rarely observed. By morphometrical analysis it was clarified that absolute depression was seen in 74% (23/31) of depressed adenomas less than 1.0 mm in diameter, and in 22% (15/69) of those more than 1.0 mm in diameter, and elevation of the muscularis mucosae was seen not in those of minute size, but in those more than 1.0 mm in diameter. From these findings it was suggested that most minute depressed adenomas would gradually develop into larger ordinary polypoid adenomas, but, among larger adenomas, exceptional ones might remain depressed.


Copyright © 1995, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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