Clinicopathological Characteristics and Pathological Mechanism of Non-steroidal Anti-inflammatory Drug(NSAID)-induced Intestinal Lesions Takashi Yao 1 , Koichi Kurahara 2 , Yumi Ohshiro 3 , Yutaka Nakashima 4 , Masafumi Oya 5 , Yoshifumi Matsushita 6 , Takayuki Matsumoto 7 , Mitsuo Iida 7 , Masazumi Tsuneyoshi 1 1Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2Division of Gastroenterology, Matsuyama Red-cross Hospital, Matsuyama, Japan 3Department of Pathology, Matsuyama Red-cross Hospital, Matsuyama, Japan 4Department of Pathology, Fukuoka Red-cross Hospital, Fukuoka, Japan 5Department of Pathology, Aso-Iizuka Hospital, Iizuka, Japan 6Department of Pathology, Chidoribashi Hospital, Fukuoka, Japan 7Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Keyword: NSAID , 腸炎 , 潰瘍 , アポトーシス pp.1691-1700
Published Date 2007/11/25
DOI https://doi.org/10.11477/mf.1403101222
  • Abstract
  • Look Inside
  • Reference
  • Cited by

 In order to elucidate the clinicopathological features of non-steroidal anti-inflammatory drug(NSAID)-induced intestinal lesions, 32 cases(53 lesions of biopsy specimens)from NSAID-induced enteritis(including ulcers), 3 cases of small intestinal diaphragm disease and 2 cases of perforated small intestinal ulcers were histologically reviewed.

 Lesions of biopsy specimens were classified into 6 types:(1) apoptotic cytotoxicity-type, (2) non-specific enteritis-type, (3) eosinophilic enteritis-type, (4) hemorrhagic enteritis-type, (5) ischemic enteritis-type, (6) collagenous colitis-type. When clinically divided into enteritis-type and ulcer-type, apoptotic cytotoxicity-type was more frequently recognized in ulcer-type(41.7%)than in enteritis-type (5.9%). In addition, all the perforated ulcers and diaphragm disease were also classified into apoptotic cytotoxicity-type. These redults suggest that apoptosis plays an important role in ulcer formation.

 NSAID-induced enteritis reveals variable clinical and histological features, which are considered to depend on the degree and combination of apoptotic cytotoxicity, inhibiting cyclo-oxygenase(inhibiting prostaglandin system), increased vascular permeability(ischemia)and allergy (eosinophilic infiltration).

Copyright © 2007, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院