Japanese

Clinicopathological Features and Growth Pattern of Epithelial Tumors of the Colorectum Takashi Yao 1 1he Second Department of Pathology, Faculty of Medicine, Kyushu University Keyword: 表面型 , 大腸癌 , 早期癌 , 陥凹型腺腫 , p53蛋白 pp.1627-1632
Published Date 1996/12/25
DOI https://doi.org/10.11477/mf.1403104473
  • Abstract
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 Clinicopathological features and p53 protein overexpression were evaluated on 165 lesions with early colorectal carcinoma 〔86 non-polypoid growth carcinomas (NPG-Ca), and 79 polypoid growth carcinomas (PG-Ca), and 35 depressed adenomas〕 . Compared with PG-Cas, NPG-Cas were more frequently found in the proximal colon and men, and were smaller in diameter, and were less frequently accompanied by adenoma. This findings suggested that there was different carcinogenesis between NPG-Ca and PG-Ca. Among NPG-Cas, there were differences in sex ratio, location, incidence of submucosal invasion and lymphovascular permeation, between the lesions with intramucosal carcinomatous component in the superficial and whole thickness portion of the mucosa (SW-type) and those in the only deep portion of the mucosa (D-type) . The SW-type accompanied submucosal invasion and lymphovascular permeation more frequently than the D-type. On the other hand, SW-type and the depressed adenoma had the same characteristics on the sex ratio, tumor location and histological architectures, which indicated that there might be common carcinogenesis between the SW-type carcinoma and the depressed adenoma. In both NPG-Ca and PG-Ca, pure carcinomas tended to have higher incidence of lymphovascular permeation and lymph node metastases than carcinomas mixed with adenomatous components. These results suggest that different pathways of carcinogenesis might result in different natural history of colorectal carcinoma. The immunohistochemical examination of p53 overexpression showed that there was no correlation between p53 overexpression and growth pattern or grades of malignancy.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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