Characteristics of Gastric Hyperplastic Polyps in Patients Non-responsive to Treatment for Eradication of Helicobacter pylori Yasuhisa Kumakura 1 , Ken Kihira 2 , Kentaro Sugano 1 1Department of Gastroenterology, Jichi Medical University 2International University of Health and Welfare Keyword: 胃過形成性ポリープ , Helicobacter pylori , 除菌療法 pp.537-544
Published Date 2002/3/25
DOI https://doi.org/10.11477/mf.1403103489
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 Hyperplastic polyp is the most common type of benign polypoid lesions of the stomach. It has been shown that this type of polyp arises from gastric mucosa characterized by chronic inflammation and atrophy, both of which factors are strongly associated with Helicobacter pylori (H. pylori) infection. Gastric hyperplastic polyps are reduced and can be cured by eradication of H. pylori in most cases. Thus, the eradication of H. pylori is considered to be an excellent non-invasive therapy for gastric hyperplastic polyps. However, this therapy does not result in the disappearance of polyps in all cases. In fact, polyps in some patients that we studied showed no significant change even after more than one year of follow-up subsequent to H. pylori eradication.

 In those whose polyps did not respond to the eradication of H. pylori, no common characteristics were observed in size, shape, localization, extension of atrophy in the background gastric mucosa, and other aspects of the polyps. Nevertheless, the following features were frequently observed in these patients: the presence of more extensive atrophy in the background gastric mucosa, low serum anti-H. pylori IgG titer observed before the eradication in spite of H. pylori positive finding, relatively poor improvement in serum pepcinogen Ⅰ/Ⅱ ratio after the eradication, and continuous elevation in serum gastrin level after the eradication.

 In relation to the indication of eradication therapy for H. pylori in patients with gastric hyperplastic polyps, further studies are required to evaluate responders and non-responders to the eradication of H. pylori.

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