Stomach and Intestine(Tokyo) Volume 34, Issue 7 (June 1999)

HTLV-1 and Gastrointestinal Tract Lesions Kazuhisa Hasui 1 1Department of Pathology Ⅱ, Faculty of Medicine, Kagoshima University Keyword: HTLV-1 , ATLL , GI(gastrointestinal)tract , Pathology , PCR pp.873-881
Published Date 1999/6/25
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 Among human T-cell leukemia virus type 1(HTLV-1) -related diseases such as adult T-cell leukemia/ lymphoma (ATLL) and HTLV-1-associated myelopathy (HAM), gastrointestinal tract (GI-tract) lesions have been studied only in ATLL. When the clinical information of HTLV-1 infection is given, the diagnosis of ATLL in the GI tract is easily made through immunohistochemical examination. But for the diagnosis of some other lymphoproliferative lesions in the GI tract polymerase chain reaction (PCR) analysis of DNA extracted from the sections is necessary. Based on autopsy ases, most ATLL lesions in the GI-tract are thought to be a part of multiple organ involvement. It has not yet been clarified whether there is primary ATLL in the GI tract or whether there are HTLV-1 lymphoproliferative lesions in the GI tract of HTLV-1 carriers or in the intermediate state of HTLV-1 infection. The immunohistochemical detection of HTLV-1 Tax (Tax) and Tax-induced induction of intranuclear regulating factor E2F will provide further evidence for the oncogenesis of ATLL. Because Wotherspoon et al reported that high grade MALT type lymphomas in the immunocompromised hosts were related to EpsteinBarr virus, MALT type lymphomas in HTLV-1 carriers must be studied in order to see the effects of HTLV-1 infection on the immunological microenvironment in cases of MALT type lymphoma.

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34巻7号 (1999年6月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院