Japanese

Clinicopathological Characteristics of Gastrointestinal T/NK Cell Lymphoma, Including Adult T-cell Leukemia/Lymphoma Morishige Takeshita 1 , Satoshi Nimura 1 , Kanta Kikuma 1 , Kozue Yamada 1 , Hideki Ishibashi 2 , Shotaro Nakamura 3 , Yoshifuku Nakayama 4 , Seiichi Okamura 5 , Naokuni Uike 6 , Hirotoshi Yonemasu 7 , Shogo Urabe 8 , Shinji Naito 9 , Seiichi Murakami1 10 , Yoshito Sadahira1 11 1Department of Pathology, Fukuoka University School of Medicine, Fukuoka, Japan 2Department of Gastroenterology and Medicine, Fukuoka University School of Medicine, Fukuoka, Japan 3Department of R/D for Surgical Support System, Center for Advanced Medical Innovation, Kyushu University, Fukuoka, Japan 4Department of Pathology, Kyushu Medical Center, Fukuoka, Japan 5Department of Hematology, Kyushu Medical Center, Fukuoka, Japan 6Department of Hematology, Kyushu Cancer Center, Fukuoka, Japan 7Department of Pathology, Oita Red Cross Hospital, Oita, Japan 8Department of Pathology, Oita Prefectural Hospital, Oita, Japan 9Department of Pathology, NHO Ureshino Medical center, Ureshino, Japan 10Department of Surgery, Amakusa Central Hospital, Amakusa, Japan 11Department of Pathology, Kawasaki Medical School, Kurashiki, Japan Keyword: GI tract , EATL , IELs , ATL/L , CD103 pp.769-781
Published Date 2014/5/24
DOI https://doi.org/10.11477/mf.1403114159
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 Intestinal EATL(enteropathy-associated T-cell lymphoma)is uncommon worldwide ; it is primarily found in northern Europe. Two main types of EATLs are classified as follows. One is composed of CD8- and, CD56- negative and CD30- positive large cell lymphoma(type I)with frequent prodromal stage of Coeliac disease, and another is CD56- positive and CD8- positive or negative medium-sized lymphoma(type II). In Japan, intestinal type I EATL is rare due to the rare incidence of Coeliac disease, and the type II group is primarily found in intestinal T/NK cell lymphoma. However, enteropathy-like lesions are partly found in the non-neoplastic mucosal layer. αEβ7integrin CD103, a homing receptor of T-IEL(intraepithelial lymphocytes), was frequently found in type II EATL cases(75%). Primary gastric or colorectal EATL was infrequent. ATL/L(Adult T-cell leukemia/lymphoma)frequently invades the GI tract, but primary GI lymphoma type ATL/L was also found(29%). An increase of reactive IELs, preserved foveolar glands in involved mucosal lesions, and frequent small nests of ATL/L in epithelial glands were detected in 29%, 65%, and 43% of the 53 cases of GI tract ATL/L examined, respectively. Involved ATL/L cells expressed CD103 in over than half of the cases(57%), suggesting that ATL/L cells were derived from T-IELs in GI tracts, in which HTLV-1 was vertically transmitted via breast milk feeding from mothers to infants.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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