Gastric Cancer Detected after Helicobacter pylori Eradication:Histopathological Features Satoshi Nimura 1 , Akiko Saka 2,4 , Kazuyoshi Yagi 3 1Department of Pathology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan 2Crystal Bldg. Clinic, Fukuoka, Japan 3Department of Gastroenterology, Niigata Prefectural Yoshida Hospital, Niigata, Japan Keyword: 除菌後発見胃癌 , 分化型胃癌 , 腸上皮化生 , 細胞形質 , 非癌上皮介在 pp.742-749
Published Date 2016/5/25
DOI https://doi.org/10.11477/mf.1403200640
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 The aim of this study was to elucidate the histopathological features of gastric cancer detected after Helicobacter pylori(H. pylori)eradication. We studied 34 lesions from 31 patients with gastric adenocarcinoma(restricted to the mucosa or invading the submucosa:30 and 4 lesions, respectively)that were detected after successful H. pylori eradication. The results obtained were as follows. Gastric cancers detected after H. pylori eradication consisted of the replacing growth-type of differentiated carcinoma showing varied atypia with a mixed gastric and intestinal phenotype. The tumor size was mainly less than 20mm in diameter. Non-neoplastic epithelial cells expressing the gastric marker MUC5AC were often seen at the surface of the intramucosal differentiated carcinoma. The surrounding mucosa of the differentiated carcinoma contained scattered plasmacytes in the lamina propria mucosae and showed microscopic features of chronic inactive atrophic gastritis with mixed gastric and intestinal type intestinal metaplasia(corresponding to incomplete intestinal metaplasia).

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