Histological Features of Low-grade MALT Lymphoma Showing Complete Regression after Helicobacter pylori Eradication and Prediction Time of Its Effectiveness Hiroko Yamashita 1 , Youichi Ajioka 1 , Hidenobu Watanabe 1 , Ken Nishikura 1 , Hideki Hashidate 1 1The First Department of Pathology, Faculty of Medicine, Niigata University Keyword: 胃MALTリンパ腫 , Helicobacter pylori除菌 pp.1389-1396
Published Date 1999/10/25
DOI https://doi.org/10.11477/mf.1403102843
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 We studied histological features of superficlal spreading low-grade MALT lymphomas of the stomach that show complete regression (CR) after eradication of H.pylori, and when we can predict CR after H.pylori eradication. The material was 25 cases of low-grade MALT lymphoma, and one case of antral low-grade MALT lymphoma which revealed a new formation of mixed low- and high-grade lymphomas in the body after CR of antral lesions. Low-grade MALT lymphoma in no response to eradication showed irregular contour of nuclei with dotted chromatin, various in size within small and medium-sized nuclei, and 20% or more of Ki-67 labelling index. CR cases at 1~2 months after eradication have been in CR status even at 6~22 months. Partial regression cases at 1~2 months after eradication also showed CR at 6~8 months after eradication. These results suggest that CR of low-grade MALT lymphoma can be predicted at 1~2 months after eradication therapy, by checking histological changes of MALT lymphoma cells.

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