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The Latest Therapy for Refractory UC-present Situation of Japan and Western Countries Ichiro Hirata 1 1Department of Gastroenterology, Fujita Health University, Toyoake, Japan Keyword: 難治性潰瘍性大腸炎 , ステロイド抵抗性・依存性UC , 免疫調節薬 , インフリキシマブ , 血球除去療法 pp.1913-1920
Published Date 2011/12/25
DOI https://doi.org/10.11477/mf.1403102739
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 In Japan, cyclosporine, tacrolimus,IFX(infliximab), and cytaheresis are opted as rescue therapies to induce the remission of refractory UC(ulcerative colitis). Because cyclosporine has a quick effect, it is recommended for cases with sever colitis that demands a quick judgment. Cytaheresis is recommended for the moderate disease that severity is not so high.

 In Europe and America, cyclosporine and IFX are mainly used as rescue therapies to induce the remission of refractory UC. The short-term results of cyclosporine, tacrolimus and IFX are good as rescue therapies for active refractory UC and many reports show the improvement rates are approximately 80%, 70% and 70%, respectively, but they require further inspection in the future. The long-term results are not so good in any of these medicines and, in half of the cases, surgery has to be postponed to after all.

 Azathioprine and 6-MP are generally used for maintenance therapy for remission of refractory UC, but the every eight weeks administration of IFX can also be selected for maintenance therapy for in cases where remission was induced by IFX.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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