胃低分化腺癌（por）の亜分類の臨床病理学的研究

Histopathological Classification of Poorly Differentiated Adenocarcinoma of the Stomach into Solid and Non Solid Types

要旨　胃癌取扱い規約の低分化腺癌（por）にはいくつかの異なる組織型がみられる．そこで低分化腺癌を形態学的に整理するために充実型と非充実型に亜分類し，臨床病理学的に検討した．その結果，充実型は平均年齢が非充実型より高く，男性に多く，一方，非充実型は男女ほぼ同数であった．また，術後の予後は充実型が良好であった．更に，c-erbB-2遺伝子産物の陽性率は低分化腺癌は高分化腺癌より低く，充実型のみに陽性例が認められた．以上より，組織形態ならびに臨床病理学的に低分化腺癌を充実型と非充実型に亜分類することが可能と考える．

　Several histological types other than well and moderately differentiated adenocarcinomas are included in poorly differentiated adenocarcinoma of the stomach. Poorly differentiated adenocarcinoma can be histologically subclassified into solid and non solid types. Solid type occurred more frequently in male than in female, while non solid type occurred with almost the same frequency in both sexes. Mean age of patients was higher for solid type than for non solid type. Solid type had a better survival rate after operation by Kaplan-Meier's method than non solid type. We thus propose that poorly differentiated adenocarcinoma of the stomach is classified into solid and non solid types not only because of histological difference but also etiological and prognostic difference.