The Pathological Diagnosis of Duodenal Neoplasms and Neoplasm-like Lesions:Standard Diagnosis and Clinicopathological Characteristics of Adenoma and Carcinoma Hiroshi Tanabe 1 , Akinori Iwashita 1 , Seiji Haraoka 1 , Keisuke Ikeda 1 , Kaname Oshige 1 , Atsuko Ota 1 , Takao Kanemitsu 1 1Department of Pathology, Chikushi Hospital, Fukuoka University, Chikushino, Japan Keyword: 十二指腸腺腫 , 分類 , 十二指腸癌 , 診断基準 , 細胞分化 pp.1587-1595
Published Date 2011/10/25
DOI https://doi.org/10.11477/mf.1403102377
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 We studied surgically and endoscopically extracted specimens that were histopathologically examined at the Department of Pathology, Chikushi Hospital, Fukuoka University, Japan, and evaluated standard diagnosis and clinicopathological characteristics of duodenal adenoma(28 lesions)and carcinoma(17 lesions).

 We had classified adenomas according to tumor origin and mucin phenotype as follows : (1) intestinal type, (2) gastric type, (3) Brunner's gland type, (4) unclassified type, and we had classified intestinal type adenomas according to cell differentiation as follows : a. Paneth cell rich type, b. Argentaffin cell rich type, c. Intermediate type, d. With endocrine cell nests type.

 We thought that the point of discrimination between adenoma and adenocarcinoma(including borderline malignancy lesions)was cell differentiation such as goblet cell,Paneth cell, and argentaffin cell, and the degree of cellular and structural atypia. For example, the adenomatous glands showed cell differentiation of various degree, but carcinomatous glands had no cell differentiation or had it excessively. The glands of adenomas were round, oval, and smooth and regular structures, but carcinomatous glands were irregular structures with brunch and conglutination.

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