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Kaposi's Sarcoma of the Gastrointestinal Tract in HIV Infection, Report of Two Cases Eiichi Ogawa 1 , Masayuki Murata 1 , Hiroaki Ikezaki 1 , Takeshi Ihara 1 , Koji Takayama 1 , Kazuhiro Toyoda 1 , Mosaburo Kainuma 1 , Yasunori Sawayama 1 , Norihiro Furusyo 1 , Motohiro Esaki 2 , Takayuki Matsumoto 2 , Ayako Goto 3 , Hidetaka Yamamoto 3 , Jun Hayashi 1 1Department of General Internal Medicine, Kyushu University Hospital, Fukuoka, Japan 2Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 3Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Keyword: HIV , highly active antiretroviral therapy , Kaposi肉腫 , human herpesvirus-8 , pegylated liposomal doxorubicin pp.303-309
Published Date 2011/3/25
DOI https://doi.org/10.11477/mf.1403102158
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 KS(Kaposi's sarcoma)is commonly observed in untreated male homosexual human immunodeficiency virus infected individuals and is associated with advanced immune deficiency. The etiology of KS is thought to be human HHV-8(human herpesvirus-8), and KS of the gastrointestinal tract is usually asymptomatic.

 〔Case 1〕A 23-year-old male Japanese was diagnosed with AIDS(acquired immunodeficiency syndrome)and KS, which was found on endoscopy not only in the duodenum and upper jejunum, with several ulcerous lesions, but in multiple organs such as the lungs, lymph nodes, and heart. Histopathlogy showed a proliferation of spindle cells positive for CD31, D2-40 and HHV-8. Although HAART(highly active antiretroviral treatment)and chemotherapy(pegylated liposomal doxorubicin)provided temporary improvement, five months after initiation of the treatments the patient died from KS of the lung.

 〔Case 2〕A 35-year-old male Japanese was diagnosed with AIDS and KS, which was found on endoscopy from the esophagus to the ascending colon. Histopathlogy showed a proliferation of spindle cells positive for CD31,CD34 and HHV-8. HAART has had a favorable influence on HHV-8 replication inhibition, and the patient has achieved complete remission of KS.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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