Short-term and Long-term Effects of Sulindac on Colonic and Duodenal Lesions in Uncolectomized Familial Adenomatous Polyposis Takayuki Matsumoto 1 , Ritsuko Fujisawa 1 , Motohiro Esaki 1 , Shotaro Nakamura 1 , Shinichiro Yada 1 , Tomohiko Moriyama 1 , Minako Hirahashi 2 , Takashi Yao 2 , Mitsuo Iida 1 1Department of Medicine and Clinical Science, Graduate school of Medical Scieneces, Kyushu University, Fukuoka, Japan 2Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Keyword: 非ステロイド性消炎鎮痛薬 , chemoprevention , 大腸腺腫 , 家族性大腸腺腫症 pp.1767-1780
Published Date 2007/11/25
DOI https://doi.org/10.11477/mf.1403101230
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 We retrospectively investigated short-term and long-term effects of sulindac(SU)on colonic and duodenal lesions in patients with uncolectomized familial adenomatous polyposis(FAP). Oral SU for 12 months induced significant decreases in the number and the size of colonic polyps in 11 patients with FAP. In contrast, colonic lesions in 6 FAP patients without SU remained unchanged for 12 months. The effect of SU was more predominant in the proximal colon than in the disatal colorectum, but it was unrelated to the site of germline APC mutation. In 8 patients who were treated by SU during the subsequent clinical course, small and nonpolypoid lesions were continuously identified. Furthermore, colonoscopy showed that in 3 patients semipedunculated or nodular-aggregating lesions increased in size. In 5 patients with duodenal adenomatosis, the duodenal lesions remained unchanged even after long-term SU administration. These findings suggest that SU induces regression of colorectal lesions in FAP, although the effect seems to be restricted to diminutive lesions.

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