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要旨 欧米ではcollagenous colitisおよびlymphocytic colitisは慢性水様性下痢の原因の10~20%を占めると考えられている.疫学研究の結果から,collagenous colitisの人口10万人当たりの年間発病率は2.3~7.1と報告されており,近年,増加傾向にある.発症年齢は58~70歳であり,性比は女性が83~89%を占めている.collagenous colitisの病因については薬剤起因性の他に遺伝,胆汁酸吸収不良,感染症,一酸化窒素,コラーゲン代謝異常などの関与が考えられている.しかし,いまだ完全に解明されてはいないのが現状である.
In western countries, the diagnosis of collagenous colitis and lymphocytic colitis are made in 10-20% of cases investigated for watery diarrhea. Based on some epidemiologic studies, annual incidence of collagenous colitis was 2.3~7.1/100,000 inhabitants. Some investigators reports rising incidence of collagenous colitis. The median age at diagnosis of collagenous colitis was 58~70 years old and female ratio was 83~89%. Several theories on the etiology of collagenous colitis, such as drugs, genetics, bile acid malabsorption, infections, nitric oxide and abnormal collagen metabolism, have been investigated. Nevertheless, the cause of collagenous colitis has not been sufficiently clarified.
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