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Collagenous Colitis: Clinico-pathological Characteristics, Pathogenesis and Differential Diagnosis Ryoji Kushima 1 , Akiko Matsubara 1 1Clinical Laboratory Division, National Cancer Center Hospital, Tokyo Keyword: collagenous colitis , 臨床病理学的特徴 , 病態発生 pp.1955-1965
Published Date 2009/12/25
DOI https://doi.org/10.11477/mf.1403101813
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 To clarify the clinico-pathological characteristics and pathogenesis of collagenous colitis, we analyzed clinical and pathological findings of 24 cases(mean 69.8 years old, m : f=1 : 3)of collagenous colitis. Symptoms of the patients were diarrhea(20 cases)and positive occult blood test(2 cases). However, two patients had no symptoms. In 19 of 23 cases(82.6%), abnormal endoscopic findings were reported, such as “minimal changes”(10 cases)and “linear mucosal defect or ulcer”(9 cases). Among 9 patients with linear mucosal defect or ulcer, 8 patients had a history of taking lansoprazole and/or NSAIDs. Not only the deposition of a collagen band but mononuclear and polymorphonuclear cell infiltration with degeneration of the superficial mucosa have been demonstrated to be important findings for a correct differential pathological diagnosis. We attempted to typify the macroscopic findings and discuss the pathogenesis of collagenous colitis.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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