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Development and Progression of UC-associated Cancer Investigated from Clinical Aspects Yasushi Iwao 1 , Makoto Naganuma 1 , Taku Kobayashi 1 , Tadakazu Hisamatsu 1 , Susumu Okamoto 1 , Nagamu Inoue 1 , Haruhiko Ogata 1 , Toshifumi Hibi 2 , Hirotoshi Hasegawa 3 , Syuji Mikami 3 , Makio Mukai 4 , Yoshinori Sugino 5 1Center for Comprehensive and Advanced Medicine, Keio University School of Medicine, Tokyo 2Division of Gastroenterology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 3Division of General and Gastrointestinal Surgery, Department of Surgery, Keio University School of Medicine, Tokyo 4Department of Diagnostic Pathology, Keio University School of Medicine, Tokyo 5Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo Keyword: 潰瘍性大腸炎 , UC関連癌 , dysplasia pp.1925-1934
Published Date 2008/12/25
DOI https://doi.org/10.11477/mf.1403101537
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 An increased risk of ulcerative colitis-associated cancer(UCAC)has been reported in patients with long-standing ulcerative colitis(UC)and cancer surveillance is recommended. Because the early detection of UCAC by colonoscopy is difficult, the natural course and the progression rate of UCAC in the early stage is still unknown. We analyzed clinical features and risk factors of 43cases(71 lesions)of UCAC/dysplasia with retrospective follow-up. The average duration of UC at cancer diagnosis was 14 years. Forty two cases of 43(97.7%)of HCAC/dysplasia were classified as extensive colitis or left-sided colitis. Fifty three lesions of 71(74.6%)were located in the rectum and sigmoid colon. Twenty six cases of 43(60.5%)were in the clinically active stage and all of the 71 lesions had severely or moderately active inflammation around them. Therefore, it was suggested that treatment strategy consider mucosal healing is essential for prevention of cancer development and progression in UC. In addition, we showed here some lesions whose endoscopic findings could be followed by colonoscopy.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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