Diagnosis and Pathophysiology of Protein-losing Gastroenteropathy Chikako Watanabe 1 , Ryota Hokari 1 , Soichiro Miura 1 1National Defense Medical College Internal Medicine, Tokorozawa, Japan Keyword: 低アルブミン血症 , α1-アンチトリプシンクリアランス試験 , 腸リンパ管拡張 , 脂肪転送障害 , 低γグロブリン血症 pp.731-734
Published Date 2008/4/24
DOI https://doi.org/10.11477/mf.1403101358
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 Protein-losing gastroenterolopathy is a syndrome characterized by albumin loss from the gastrointestinal tract. The main clinical presentation is hypoproteinemia and edema, often accompanied with diarrhea. It is categorized into primary and secondary protein-losing.

 The primary protein-losing enteropathy is mainly due to lymphatic abnormalities of the GI tract, while the secondary one is due to various disorders including increased vascular permeability, mucosal inflammation, and GI neoplasm. Protein-losing is diagnosed by the alpha-1 antirypsin clearance test and albumin scintigraphy. If there is lymphangiectasia of the intestinal mucosa, it can be recognized endoscopically as white villi or white spots, and histologically confirmed.

 Protein-losing gastroenteropathy should be managed carefully in consideration of the accompanying malnutrition and immunological abnormalities.

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