6)Behçet病

Behçet's Disease

　Behçet病は口腔潰瘍，陰部潰瘍，眼病変，皮膚病変の4症状の組み合わせで成り，副症状として，関節炎，副睾丸炎，腸管(消化管)潰瘍，血管病変，中枢神経系病変が出現する全身性疾患である．消化管潰瘍は，すべての消化管に発生するが，回盲部に好発する．回盲部の主潰瘍は辺縁鋭利で円形～卵円形を呈し大きく深い．一方，小腸や結腸の潰瘍は多発し，より小型で，しばしばアフタ様を呈する．潰瘍性大腸炎，Crohn病との鑑別は通常容易である．

　Behçet's disease is a tetrad of oral ulcers, genital ulcers, ocular lesions and skin lesions which often recur. Additional features are arthritis, epididymitis, gastrointestinal ulcers, vascular lesions and central nervous system involvement. Therefore, it is a multi-organ disease.

　As for gastrointestinal ulceration, it could occur anywhere throughout the entire gastrointestinal tract, although manifestations in the ileocecal region are the most common. The major manifestation in the ileocecal region is a large, round or oval-shaped, deep, well demarcated ulceration. On the other hand, ulcerations in the small bowel and/or colon are multiple and smaller, often appearing aphthous.

　The colitis of Behçet's disease is usually distinguishable from ulcerative colitis and Crohn's disease.