Low Grade MALT Lymphoma of the Stomach Transformed to Diffuse Large B-cell Lymphoma after the Eradication of Helicobacter pylori Tomonori Anbo 1 , Akimichi Imamura 1 , Toshihiro Sato 2 1Department of Gastroenterology, Sapporo Kosei Hospital 2Department of Clinical Pathology, Sapporo Kosei Hospital Keyword: , MALTリンパ腫 , Helicobacter pylori , 除菌療法無効 pp.583-588
Published Date 2002/3/25
DOI https://doi.org/10.11477/mf.1403103496
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 A 51 year-old-female was admitted to our hospital complaining of left hypochondralgia. Gastrointestinal endoscopy revealed edematous, subtranslucent and discolored mucosa from the lower gastric body to the antrum. Small erosions were observed on the surface of the lesser curvature of the gastric angle. These findings suggested a malignant lymphoma spread out in the mucosal and submucosal layer of the gastric wall. Rapid urease test was positive. The histological findings of the biopsy specimens showed an extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type. Six weeks after eradication therapy for HP, a flat mucosal elevation appeared in the lesser curvature of the angle. Total gastrectomy was performed because the follow-up findings suggested the progression of the disease. The investigation of the resected specimen led us to change the preoperative diagnosis to diffuse large B-cell lymphoma. Additional systemic chemotherapy (6 courses of CHOP) was performed. The patient has been in complete remission for more than 4 years.

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