Cowden's Disease Kiyoshi Fujisawa 1 1Department of Endoscopic Diagnostics and Therapeutics, Kyushu University Hospital Keyword: Cowden病 , 消化管ポリポーシス , 皮膚粘膜病変 , 過誤腫 , PTEN遺伝子 pp.465-472
Published Date 2003/4/24
DOI https://doi.org/10.11477/mf.1403100900
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 Cowden's disease is an autosomal-dominant hereditary disease characterized by hamartomatous and neoplastic lesions in multiple organs. The disease is accompanied by gastrointestinal polyposis. Unlike other gastrointestinal polyposis, polyps in Cowden's disease occur predominantly in the esophagus, in the stomach, and in the distal large intestine. Histologically, polyps in Cowden's disease manifest hyperplastic or hamartomatous changes. The responsible gene for Cowden's disease has recently been identified and referred to as PTEN. The function of PTEN protein is under investigation.

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