Examination of Drug-Induced Ulcers, Especially NSAIDs and Low Dose Aspirin Yuji Mizokami 1 , Koichi Shimokobe 1 , Takashi Nishigami 2 , Masanori Ito 1 , Hisashi Takehara 1 , Junichi Iwamoto 1 1Department of Gastroenterology, Tokyo Medical University, Kasumigaura Hospital, Ibaraki, Japan 2Department of 2nd Pathology, Hyogo College of Medicine, Nishinomiya, Japan Keyword: NSAIDs , 低用量アスピリン , 消化性潰瘍 , H. pylori pp.1045-1051
Published Date 2006/6/25
DOI https://doi.org/10.11477/mf.1403100804
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 With the advent of our aging society, the number of patients with ischemic heart disease and cerebrovascular disease has increased. This has resulted in the widespread use of low-dose aspirin. In this study we classified peptic ulcers diagnosed recently at our hospital by endoscopy, into low dose aspirin induced(Group A), non-aspirin NSAIDs induced(Group N)and non-aspirin, non-NSAIDs induced(Group C). The proportion of ulcers in each group(A, N, and C)was 7 %, 18 %, and 75 % respectively. Bleeding events such as hematemesis, melena and anemia occurred in 53.6 %, 45.2 %, and 31.2 % of the subjects in each group(A, N and C)respectively, and the frequency of these events was higher in Group A. The ratio of ulcers located in the antrum in each group(A, N, and C)was 24 %, 32 %, and 16 % respectively. The ratio of antral ulcers was higher in Group N than in Group C. There was no significant difference between Groups A and C. With regard to the size of ulcers, those in Group A tended to be smaller than those in Group N. There was no difference in the number of ulcers among the groups. There was no difference in the prevalence of H. pylori between Group A and C. However, prevalence was significantly lower in Group N than in Group C. The score of multi nuclear white blood cell infiltration in the antral mucosa was lower in Group A and N than in Group C.

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