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Chemoradiotherapy for Superficial Esophageal Squamous Cell Carcinoma Keiko Minashi 1 , Toshihiko Doi 1 , Manabu Muto 1 , Kiyomi Mera 1 , Tomonori Yano 1 , Atsushi Ohtsu 1 1Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan Keyword: 食道表在癌 , 化学放射線療法 , 臨床試験 , 救済治療 , 晩期毒性 pp.1467-1474
Published Date 2006/9/25
DOI https://doi.org/10.11477/mf.1403100662
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 Treatment outcomes of definitive chemoradiotherapy for superficial esophageal carcinoma beyond the indications for endoscopic mucosal resection (EMR) were analyzed. There were 41 patients with stage I esophageal squamous cell carcinoma who underwent definitive chemoradiotherapy. Of the 41, 36 (87.8%) patients achieved a complete response with 1-, 3-, and 5-year survival rates of 97.5%, 79.4%, 66.9%, respectively. Salvage treatments, predominantly with EMR, were safely undergone for local residual/recurrent tumors. However, three (8%) of 36 CR patients died without cancer, which event might have been caused by late toxicity. A multi-institutional phase II study of definitive chemoradiotherapy for stage I esophageal cancer (JCOG9708) has resulted in good outcomes with a complete response rate of 96% and a 2-year survival rate of 93%. These results suggested that chemoradiotherapy might achieve outcomes comparable with radical surgery in this stage. A randomized trial comparing surgery with definitive chemoradiotherapy (JCOG0502) will soon be initiated.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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