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要旨●化学放射線療法(CRT)後に再発した食道扁平上皮癌に対するESDの治療成績を検討した.一括切除率は86%で,重篤な偶発症はなかった.完全寛解(CR)後再発群と部分寛解(PR)後再発群を比較したところ,CRTから再発発見までの期間に有意差を認めたが,それ以外の臨床的差異はなかった.局所再発はCR群で1例,PR群で3例に認め,うち3例にESDを施行し,1例が再発後に手術を受けた.原病死はすべてPR群の3例に認めた.CRT後の遺残・再発病変はESDで局所制御可能な場合もあるが,特にPR群では全身制御の重要性が示唆された.
We assessed the therapeutic outcomes of endoscopic submucosal dissection(ESD)in patients with recurrent esophageal squamous cell carcinoma following chemoradiotherapy(CRT). The en bloc resection rate was 86%, with no notable severe adverse events. Comparing patients with recurrence following complete response(CR)and those with recurrence following partial response(PR)revealed a significant difference only in the interval between CRT and detection of the recurrent lesions, with no other notable clinical differences. One patient in the CR group and three patients in the PR group developed recurrence. Three patients underwent ESD, and one of them required subsequent surgery owing to re-recurrence. Disease-specific death occurred in three patients, all belonging to the PR group. Although ESD can achieve local control of residual or recurrent lesions after CRT, systemic disease control is crucial in the PR group.

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