Gastrointestinal Manifestations in Immuno-dysregulatory Conditions Takayuki Matsumoto 1 , Mitsuo Iida 2 1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Keyword: 免疫不全 , 移植片対宿主病 , X線所見 , 内視鏡所見 pp.1135-1145
Published Date 2005/7/25
DOI https://doi.org/10.11477/mf.1403100137
  • Abstract
  • Look Inside
  • Reference
  • Cited by

 We reviewed radiographic and endoscopic features of gastrointestinal (GI) involvement in immunodeficiency diseases and graft-versus-host disease (GVHD). Although GI involvement of primary immunodeficiency with lymphocyte defect has been described to some extent, protozoal or parasitic infestations accompanied by malabsorption are major GI manifestations. In contrast, chronic colitis frequently occurs in primary leukocyte dysfunction such as chronic granulomatous disease and glycogen storage disease. The radiographic and endoscopic findings of chronic colitis mimic those found in inflammatory bowel diseases. Protozoal and parasitic infestations are also the major small intestinal involvement in HIV or HTLV-1 infection. In addition, fungal infection of the esophagus and GI ulcers induced by viral infection occur in cases of acquired immunodeficiency. In GVHD, heterogeneous gastrointestinal lesions are found anywhere within the GI tract. However, mucosal edema and sloughing are characteristic of the disease. There seems to be a need to interpret radiographic and endoscopic features of individual GI infections, because immuno-dysregulatory conditions are predisposed to the infection.

Copyright © 2005, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院