Non-Squamous Cell Carcinomas of the Esophagus : The National Cancer Center Hospital, Tokyo, Experience Hiroyasu Igaki 1 , Hoichi Kato 1 1Department of Surgery, National Cancer Center Hospital Keyword: 食道癌 , 扁平上皮癌 , 特殊組織型 pp.354-362
Published Date 2005/3/25
DOI https://doi.org/10.11477/mf.1403100042
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Among the 2,370 patients with malignant tumors of the esophagus treated from January 1988 to December 2003 at the National Cancer Center Hospital in Tokyo, there were 28(1.2 %)with Barrett adenocarcinoma,8(0.3 %)with adenocarcinoma of the esophagogastric junction,17(0.7 %)with adenosquamous carcinoma,1(0.04 %)with adenoid cystic carcinoma,22(0.9 %)with basaloid-squamous carcinoma,32(1.4 %)with undifferentiated carcinoma,1(0.04 %)with leiomyosarcoma,21(0.9 %)with carcinosarcoma, and 10(0.4 %)with malignant melanoma.

 The present report documents the results of our experience with those specific groups of malignant tumors.

 Surgical resection is the first choice of treatment for patients with leiomyosarcoma.

 Among patients with small cell type of undifferentiated carcinoma, many were treated with chemo or chemoradiation therapy because they were classified in the advanced stage with clinically verified cervical lymph node metastasis positive or distant organ metastasis. Surgical resections achieved long-term survival for patients with a few metastatic lymph nodes.

 Optimal treatment for patients with primary malignant melanoma of the esophagus has not been established. Surgical resection is thought to be the main approach to treatment. However, patients with malignant melanoma tended to have distant organ metastasis within a few months after surgery even though they had exhibited early stage signs of the disease. Based on the results of this study, we consider patients with malignant melanoma should be treated using a non-surgical approach.

 Treatment for patients with other specific types of malignant tumors should be performed according to the treatment strategy for those with squamous cell carcinoma.

Copyright © 2005, Igaku-Shoin Ltd. All rights reserved.


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