Non-Squamous Cell Carcinoma of the Esophagus Masao Hosokawa 1 , Sachiko Kaida 1 , Takaya Kusumi 1 , Yasunori Nishida 1 , Akira Kawaguchi 1 1Department of Surgery, Keiyukai Sapporo Hospital Keyword: 食道癌 , 特殊組織型癌 , 小細胞癌 , 悪性黒色腫 , 食道腺癌 pp.363-370
Published Date 2005/3/25
DOI https://doi.org/10.11477/mf.1403100043
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In a series of 2,521 patients with esophageal malignant neoplasms treated between 1981 and 2003, specific type cancers presenting with a non-squamous cell carcinoma(non-SCC)were seen in 73 patients(2.9 %). Treatment results of non-SCCs were compared with those of squamous cell carcinoma(SCC ; n=2,448 ; 97.1 %)in this study. Non-SCCs consisted of adenocarcinoma(n=36 ; arising from Barrett's esophagus in 17 cases, and from ectopic gastric mucosa in 6 cases, and others), adenosquamous carcinoma(n=2), adenoid cystic carcinoma(n=4), basaloid carcinoma(n=4), undifferentiated carcinoma(n=17), carcinosarcoma(n=6)and malignant melanoma(n=4).

 In patients with undifferentiated carcinoma, those with small cell carcinoma had an extremely poor prognosis. Surgical resection was indicated for cases in which the depth of invasion was limited to the submucosa without metastasis to the lymph nodes, but most patients were treated mainly with chemotherapy due to the advanced clinical stage of their carcinomas.

 Regarding malignant melanoma, surgical resection was undertaken for as many patients as possible, because chemo- and/or radiotherapy were thought to be ineffective against malignant melanoma. The true impact of chemotherapy on malignant melanoma is not known with certainty due to the shortage of cases.

 Treatment for other non-SCCs is performed according to therapeutic strategies similar to those of SCC, because treatment results stratified according to clinical stages are almost equivalent to those of SCC.

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