アスピリン点眼が奏効したコンタクトレンズによる急性眼痛

Topical aspirin solution relieved acute pain due to contact lens wear

　コンタクトレンズ装用により急激な眼痛を伴う急性角膜低酸素症とか装用過多症候群と呼ばれる症状を来す患者を見ることは決して稀ではないが，これまでこの症状に対する有効な治療法はない．この症状を来して2日間の激しい眼痛を伴い，自発開瞼ができなかった26歳の女性にアスピリン点眼をしたところ，点眼後数秒で眼痛は軽減して自発開瞼ができるようになり，更に15分間隔で2時間の点眼により，眼痛はほぼ完全に消失して球結膜充血も消退した．翌日の再診時には角膜上皮剥離を残すのみで，眼痛はなく球結膜充血もほぼ消退していた．この症状に対するアスピリン点眼の効果は劇的なものであった．

A 26-year-old woman presented with severe ocular pain and lacrimation due apparently to soft contact lens. She manifested erosion in the central cornea and bulbar hyperemia. After conventional topical treatments proved futile in alleviating the pain and lacrimation the next day, the eye was treated by instillation of solution containing 4% aspirin DL-lysine. In less than 10 seconds, the eye pain drastically diminished and the patient could open her affected eye. After a total of 8 instillations during the next 2 hours, the ocular pain completelydisappeared with reduction in bulbar hyperemia.

Symptoms of ocular pain, photophobia and la-crimation in contact lens wearers are referred as acute corneal hypoxia or acute overwear syndrome. Topical administration of solution containing aspi-rin DL lysine proved useful in preventing disruption of blood-aqueous barrier after paracentesis or laser irradiation of the iris. A similar mechanism may underlie the observed effect of the preparation in the current case.

Rinsho Ganka (Jpn J Clin Ophthalmol) 42(2) : 179-182, 1988