脊髄前角細胞にエオジン好性核封入体を認める特異な進行性の筋萎縮症例

A CASE OF PROGRESSIVE MUSCULAR ATROPHY WITH EOSINOPHILIC INTRANUCLEAR INCLUSION-BODY IN THE ANTERIOR HORN CELLS OF SPINAL CORD

I．はじめに

　臨床上，一応脊髄性進行性筋萎縮症を思わせながら，その進行が早く，発病後1年7ヵ月で死亡し，剖検上脊髄前角細胞核封入体を認め，Postencephalitic amyo—trophyと思われる特異な病理所見を呈した興味ある症例を経験したので報告する。

There was á case, 29 year-old male, who initially had muscle weakness of distal portion at the upper extremity without any cause, gradually showed progressive muscle weak-ness and atrophy over the whole body and died with course of one year and seven months.

By autopsy the following findings were revealed; sequel of meningo-encephalitis during infancy, dominant degeneration and loss of ganglion cells in the grey matter of the spinal cord excluding the lateral horn and eo-sinophilic inclusion-body in the nuclei of many anterior horn cells. Also, severe degree of glio-sis throughout the grey matter of the spinal chod, and so-called marginal pallor in the white matter were seen. The anterior root showed severe atrophy but the posterior root showed no change.

It may be considered that on the basis of autopsy findings as previously mentioned, this case is a rare one included in category of postencephalitic amyotrophy.