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- Abstract 文献概要
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我々は外来通院中に水中毒により血中ナトリウム値が118mEq/lとなり,重度意識障害,けいれん発作および噴出性嘔吐などを来した精神分裂病の61歳女性例を経験した。原因薬剤はpimozideと考えられたが,本剤による低ナトリウム血症は我々の知るかぎりでは小児科での精神発達遅滞3例が報告されているだけで,精神科分野での報告を見い出せなかったため,文献的考察も併せて報告する。
With the view of recording it in medical literature, we report a case of an outpatient with schizophrenia who presented hyponatremia induced by pimozide. The patient was a 61-year-old Japanese female who had taken 2 mg/day of pimozide for more than 20 years since 1974 because of auditory hallucination and delusions of persecution. In June of 1994, she suddenly showed disturbance of consciousness, speech disturbance, gait disturbance, convulsion and projectile vomiting. Laboratory data showed 118 mEq/ l of serum natrium, 10,800/mm3 of WBC, 376×104/mm3 of RBC, 11.4g/d/ of Hb and 33.5% of Ht. Computed tomography examination showed a slightly edematous image of the brain but there was no bleeding. After admission, her general condition immediately improved with slow correction of serum hyponatrium by fluid therapy. On the 8 th day she was discharged without any symptoms or remaining abnormal laboratory data.
There have been reports that haloperidol, fluphenazine, thioridazine, amitriptyline, desipramine and carbamazepine have induced compulsive water drinking, water intoxication and hyponatremia, but, to our knowledge, there has been only one report of pimozide-induced hyponatremia in the field of pediatrics and no previous report in psychiatry.

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