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Clinicopathological Features of Superficial Esophageal Squamous Cell Carcinoma in Patients with No History of Smoking and Alcohol Consumption Yoko Tateishi 1 , Takehide Fukuchi 2 , Kingo Hirasawa 2 , Makoto Sugimori 3 , Hideaki Mitsui 1 , Koji Okudela 1 , Shin Maeda 4 , Yoshiaki Inayama 5 1Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan 2Division of Endoscopy, Yokohama City University Medical Center, Yokohama, Japan 3Department of Clinical Cancer Genomics Yokohama City University Medical Center, Yokohama, Japan 4Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan 5Department of Diagnostic Pathology Yokohama City University Medical Center, Yokohama, Japan Keyword: 食道表在癌 , 習慣的喫煙・飲酒歴 , 扁平上皮癌 , GERD pp.1359-1366
Published Date 2022/10/25
DOI https://doi.org/10.11477/mf.1403203017

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 The main risk factors for ESCC(esophageal squamous cell carcinoma)are cigarette smoking and alcohol consumption. However, a minority of patients had no history of exposure to these risk factors ; thereby, the etiology remains unknown in these patients. The clinicopathological features of superficial ESCC in never smokers and never drinkers were investigated. The cases were collected and discussed at the 81st Congress of the Japanese Research Society for Early Esophageal Cancer and Chromoendoscopy. One hundred and ten superficial ESCCs in 104 never smoker-never drinkers and 767 superficial ESCCs in 544 patients with a history of smoking and alcohol consumption were retrospectively investigated to show characteristic clinicopathological features such as female gender, absence of synchronous/metachronous cancer, grade A Lugol-voiding lesion, presence of gastroesophageal reflux disease, tumor location at the middle thoracic/posterior wall, type 0-IIa macroscopic type, and squamous cell carcinoma in situ with frequent clear zonal squamous differentiation.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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