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Coexisting High-grade Anal Intraepithelial Neoplasia and Condyloma Acuminatum Treated with Endoscopic Submucosal Dissection, Report of a Case Kenji Yamazaki 1 , Hitoshi Iwata 2 , Ryoji Kushima 3 , Hiroyuki Tanaka 4 , Hironao Ichikawa 1 , Naoki Mita 1 , Tomoyuki Satake 1 , Masaya Ohnishi 1 , Takayuki Nakanishi 1 , Junji Nagano 1 , Nobuhiro Ando 1 , Junichi Sugihara 1 , Hiroshi Araki 5 , Masahito Shimizu 5 1Department of Gastroenterology, Gifu Prefectural General Medical Center, Gifu, Japan 2Department of Diagnostic Pathology, Gifu Prefectural General Medical Center, Gifu, Japan 3Department of Clinical Laboratory Medicine and Diagnostic Pathology, Shiga University of Medical Science, Otsu, Japan 4Department of Gastroenterology, Tokai Central Hospital, Gifu, Japan 5Department of Gastroenterology, Gifu University School of Medicine, Gifu, Japan Keyword: anal intraepithelial neoplasia , 尖圭コンジローマ , human papilloma virus , 拡大内視鏡 , ESD pp.1487-1495
Published Date 2016/10/25
DOI https://doi.org/10.11477/mf.1403200754

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 A woman in her 80s underwent colonoscopic examination after a positive fecal occult blood test. Colonoscopy revealed a flat elevated whitish lesion, measuring approximately 20mm, located in the anal canal. We clearly confirmed the margin of this lesion using indigo carmine dye. Narrow-band imaging without magnification demonstrated this lesion as brownish and elevated ; magnifying colonoscopy with narrow-band imaging revealed loop-like and meandering microvessels resembling the intraepithelial papillary capillary loops observed in early-stage squamous esophageal carcinoma. We performed ESD(endoscopic submucosal dissection)for en bloc resection of the lesion. The lesion was pathologically diagnosed as an anal(squamous)intraepithelial neoplasia, low and high grade, with condyloma acuminatum. Immunostaining for p16 was strongly positive. These findings suggest that the tumor was strongly associated with oncogenic human papilloma virus infection.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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