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Difference in Endoscopy-based Diagnosis of Superficial Barrett's Esophageal Adenocarcinoma in Japan and Europe Manabu Takeuchi 1,2 , Gen Watanabe 3 , Satoru Hashimoto 2 , Yuichi Sato 4 , Yoichi Ajioka 3 , Shyuji Terai 2 , Andreas Probst 5 , Helmut Messmann 5 1Department of Gastroenterology, Nagaoka Red Cross Hospital, Niigata, Japan 2Department of Gastroenterology and Hepatology, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan 3Division of Molecular and Diagnostic Pathology, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan 4Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata, Japan 5Department of Gastroenterology, Klinikum Augsburg, Augsburg, Germany Keyword: Barrett食道癌 , 内視鏡診断 , surveillance , 日本 , 欧州 pp.1345-1351
Published Date 2016/9/25
DOI https://doi.org/10.11477/mf.1403200730

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  • Abstract
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 In Japan, a diagnosis of superficial BEA(Barrett's esophageal adenocarcinoma)is typically made using a detailed endoscopic analysis, which is proceeded by a targeted biopsy of the lesion. In contrast, in Europe and the United States, BEA is diagnosed using a random biopsy as defined in the Seattle protocol. The reasons these different approaches are used include the following:1)Europe has a low frequency of early gastric cancer, and endoscopic screening for gastric cancer is not routinely performed ; 2)Endoscopic images in Europe are of a lower resolution compared with those obtained using the endoscopic systems employed in Japan, 3)As endoscopic images of biopsy specimens and the resected specimens are not obtained, there does not appear to be a need to improve endoscopic diagnostics ; 4)In Europe, there is a higher rate of cases of LSBE(long-segment Barrett's esophagus), in which the lesion is flat, exhibits lateral extensions, and is difficult to qualitatively diagnose.

 Expanding the use of a diagnostic approach that incorporates endoscopy and targeted biopsy in regions outside of Japan is necessary to provide improvements in the diagnosis of superficial BEA.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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