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Mucosa-associated Lymphoid Tissue Lymphomas of the Stomach and Rectum Madoka Takao 1 , Hisatomo Ikehara 1 , Yuichiro Yamaguchi 1 , Masaki Tanaka 1 , Naomi Kakushima 1 , Kohei Takizawa 1 , Hiroyuki Matsubayashi 1 , Hiroyuki Ono 1 , Akio Shiomi 2 , Takashi Ikeda 3 , Reiko Watanabe 4 , Ichiro Ito 4 1Division of Digestive Endoscopy, Shizuoka Cancer Center Hospital, Shizuoka, Japan 2Division of Colon and Rectal Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan 3Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center Hospital, Shizuoka, Japan 4Division of Pathology, Shizuoka Cancer Center Hospital, Shizuoka, Japan Keyword: 直腸MALTリンパ腫 , 胃MALTリンパ腫 , 同時性多発 , リツキシマブ pp.1875-1883
Published Date 2011/11/25
DOI https://doi.org/10.11477/mf.1403102417

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 A 60-year-old woman was admitted to our hospital for further examination of a rectal tumor which had been investigated by colonoscopy for positive fecal occult blood. Colonoscopy revealed a submucosal tumor in the rectum, measuring 25mm in diameter.

 On the opposite side of the rectum, there was a flat elevated lesion, measuring 20mm in diameter. Upper gastrointestinal endoscopy revealed minute depression areas in the gastric body. Histological findings of the biopsy specimens from both the rectal and stomach lesions revealed mucosa-associated lymphoid tissue lymphoma. Systemic examination revealed no other infiltration of lymphoma cells and the lesions were localized to the primary sites, so this patient was diagnosed as Stage I. Helicobacter pylori eraducation therapy was attempted in this patient, but no remarkable effect was recognized in the endoscopic findings. Therefore, she was administered rituximub therapy as a second therapy. Endoscopic findings after 8 courses of rituximub therapy revealed remarkable regression of the rectum lesions, and histological findings of biopsy specimens from both the rectum and the stomach revealed disappearance of lymphoma cells.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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