新生児エリテマトーデス（NLE）の兄弟例

・新生児エリテマトーデス（NLE：neonatal lupus erythematosus）の兄弟例を経験した．母親は無症状であったが，第1子の環状紅斑を契機に精査し，無症候性Sjögren症候群と診断した．2年後に出産した第2子の男児にも生後3週より耳介の紅斑が出現し，NLEと診断した．

・NLEでは皮膚症状以外に，不可逆性の先天性心ブロックを生じることがあり，次子以降の妊娠出産時に慎重な対応が必要となる．

（「症例のポイント」より）

　

A case of siblings with neonatal lupus erythematosus

　

Nakamura, Yuka1）Takahata, Hiroaki1）Terachi, shinichi2） 1）Department of Dermatology, Yamaguchi Red Cross Hospital 2）Department of Pediatrics, Yamaguchi Red Cross Hospital

　

A 6-week-old male infant, who was the first-born infant of a 25-year-old woman, presented with erythematous annular lesions on the face and abdomen. He had positive for anti-SS-A and anti-SS-B antibodies, and was diagnosed with neonatal lupus erythematosus (NLE). His mother did not complain of any symptoms, but she was examined and diagnosed with subclinical Sjögren’s syndrome. Two years later, the patient’s younger brother, who was the second-born infant of the mother, presented with skin eruptions on the ears at 3 weeks after birth. He was also diagnosed with NLE due to positivity for anti-SS-A and anti-SS-B antibodies. Because NLE may induce irreversible congenital heart block in addition to skin symptoms, their mother needs to be carefully followed at the time of her next pregnancy and delivery.