川崎病治療後に好酸球増多を伴って発症した乳児好酸球性膿疱性毛包炎

・川崎病治療後に発症した乳児好酸球性膿疱性毛包炎（Eosinophilic pustular folliculitis：EPF）を経験した．

・持続する好酸球増多を認め，毛包周囲に好酸球の著明な浸潤を認めた．

・プレドニゾロン（PSL）とスプラタストトシル酸塩内服，ステロイド外用により，好酸球増多，皮疹ともに改善した．

（「症例のポイント」より）

　

A case of infantile eosinophilic pustular folliculitis with marked eosinophilia which accompanied treatment of Kawasaki disease

　

Sato, Atsuko1）Komine, Mayumi1）Murata, Satoru1）Ohtsuki, Mamitaro1） 1）Department of Dermatology, School of Medicine, Jichi Medical University

　

A 3-month-old boy was consulted due to erythema, papules, pustules spread on the abdomen, the face and the head along with peripheral blood eosinophilia. He was diagnosed as Kawasaki disease when he was 2-month-old. Although it was refractory to IVIG, which had been tried five times in total, fever and inflammatory reaction subsided with concomitant administration of cyclosporine in one month after the onset of the disease. Three days after the termination of cyclosporine treatment, however, erythema developed on the trunk and spread to whole body. Histopathologically, there were significant infiltrations of eosinophils in the dermis and hair follicles. Both skin rash and peripheral blood eosinophilia were improved with oral prednisolone 0.2 mg/kg/day.