糖尿病における血管石灰化の予防・治療

Prevention and treatment for vascular calcification in patients with diabetes mellitus.

　糖尿病は心血管病変や骨粗鬆症のリスクが高いことが知られている。血管の石灰化機序において，骨組織における骨代謝に類似した分子メカニズムが見いだされたことから，骨粗鬆症治療薬による糖尿病患者の血管石灰化予防が期待されている。しかし基礎研究や動物実験で得られた血管石灰化予防効果を，臨床では同様には認めてはいない。血管石灰化予防を主要評価項目とした，精緻に血管石灰化を評価する研究手法を用いた検討が望まれている。

　It has been known that diabetes mellitus is known to have a high risk of cardiovascular diseases as well as osteoporosis. Prevention and treatment of vascular calcification in patients with diabeties mellitus by anti-osteoporosis agents is prospected bcause similar molecular mechanisms in bone tissue were found in calcified lesion in blood vessels. However, the anti-vascular calcification effect has not always been observed in clinical practice in contrast to basic research and animal experiments. More optimized clinical research desined for prevention of vascular calcification as primary outcome, such as applying elaborated method for detemination of calcified lesion, is needed.