Volume 28, Issue 7 (June 2018)
Japanese

Body weight and bone/calcium metabolism. Muscle, myokines and bone/calcium metabolism. Kaji Hiroshi 1 1Department of Physiology and Regenerative Medicine, Kindai University Faculty of Medicine, Osakasayama, Japan. pp.919-926
Published Date 2018/6/28
DOI https://doi.org/10.20837/4201807919
  • Abstract
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 The interactions between skeletal muscle and bone have been noted, and muscle influences bone metabolism by secreting myokines. Myostatin is known as a myostatic factor through an inhibition of Smad2/3 signaling in muscle. It is involved in the pathophysiology of rheumatoid arthritis via a stimulation of bone resorption. Follistatin might be involved in the regulation of muscle and bone by gravity change through an attenuation of myostatin action. Irisin with energy metabolism improvement actions is related to the effects of mechanical stress or exercise on muscle and bone. The research of myokines might lead to the improvement of clinical practice of sarcopenia and osteoporosis.



基本情報

09175857.28.7.jpg
CLINICAL CALCIUM
28巻7号 (2018年6月)
電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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